The Effect of Copper Nanoparticles on Liver Function and Some Hematological Parameters in Rat
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چکیده
The objective of the present study was to evaluate the effect of copper nanoparticles (CuNPs) on liver function enzymes (ALT, AST and ALP) and some hematological parameters (RBCs, Hb, PCV and WBCs). The study included the use of 54 white male rats, which were divided into three groups. Rats in The first and second groups were injected intraperitoneally with 0.5 ml of copper nanoparticles at a dose of 20 and 40 mg/kg body weight for 3, 6 and 9 days. Rats in the control group were injected intraperitoneally with 0.5 ml of distilled water only. The blood samples were collected by heart puncture. The results revealed a significant elevation in liver function enzyme levels and significant decrease in RBCs, Hb and PCV especially at high dose with significant increase in WBC count. All results showed dose-and time-dependent.
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تاریخ انتشار 2017